维生素D与钙信号传导及胰岛素抵抗的代谢和遗传关联
Metabolic and Genetic Association of Vitamin D with Calcium Signaling and Insulin Resistance.
作者信息
Tarfeen Najeebul, Nisa Khair Ul, Ahmad Mir Bilal, Waza Ajaz Ahmad, Ganai Bashir Ahmad
机构信息
Centre of Research for Development, University of Kashmir, Srinagar, India.
Department of Environmental Science, University of Kashmir, Srinagar, India.
出版信息
Indian J Clin Biochem. 2023 Oct;38(4):407-417. doi: 10.1007/s12291-022-01105-0. Epub 2022 Dec 10.
Abstract
Various evidences have unveiled the significance of Vitamin D in diverse processes which include its action in prevention of immune dysfunction, cancer and cardiometabolic disorders. Studies have confirmed the function of VD in controlling the expression of approximately nine hundred genes including gene expression of insulin. VD insufficiency may be linked with the pathogenesis of diseases that are associated with insulin resistance (IR) including diabetes as well as obesity. Thus, VD lowers IR-related disorders such as inflammation and oxidative stress. This review provides an insight regarding the molecular mechanism manifesting, how insufficiency of VD may be connected with the IR and diabetes. It also discusses the effect of VD in maintaining the Ca levels in beta cells of the pancreas and in the tissues that are responsive to insulin.
摘要
各种证据揭示了维生素D在多种生理过程中的重要性，包括其在预防免疫功能障碍、癌症和心血管代谢紊乱方面的作用。研究证实了维生素D在控制约900个基因表达中的作用，包括胰岛素的基因表达。维生素D不足可能与包括糖尿病和肥胖症在内的与胰岛素抵抗（IR）相关疾病的发病机制有关。因此，维生素D可降低与IR相关的疾病，如炎症和氧化应激。本综述深入探讨了维生素D缺乏与IR和糖尿病之间可能存在联系的分子机制。它还讨论了维生素D在维持胰腺β细胞和对胰岛素有反应的组织中钙水平方面的作用。
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