Tsoi W F, Candlish J K, Kua E H
Ann Acad Med Singap. 1985 Jan;14(1):84-6.
This is a study to find out whether serum creatine phosphokinase activity (CPK) is raised in Oriental schizophrenic patients. CPK was found to be elevated in Caucasian schizophrenic patients more commonly during the acute period of the illness. The CPK involved is the skeletal isoenzyme CPK (MM) and not the brain isoenzyme CPK(BB). CPK elevation is associated with motor nerve and myoneural abnormalities. In this study of 150 patients the CPK activity varied from 12 to 902 mu/l with 78 patients having CPK activity above the normal range of 15-55 mu/l. This shows that Oriental schizophrenic patients may have similar pathophysiology. There is no relation between the CPK activities and the patients' age, duration of illness, presence of delusions or hallucinations, or abnormal behaviour. Such results support a genetic basis for the abnormality.
这是一项旨在查明东方精神分裂症患者血清肌酸磷酸激酶活性（CPK）是否升高的研究。在白种人精神分裂症患者中，CPK在疾病急性期更常见升高。所涉及的CPK是骨骼肌同工酶CPK（MM），而非脑同工酶CPK（BB）。CPK升高与运动神经和肌神经异常有关。在这项对150名患者的研究中，CPK活性在12至902μ/l之间变化，78名患者的CPK活性高于15 - 55μ/l的正常范围。这表明东方精神分裂症患者可能具有相似的病理生理学。CPK活性与患者年龄、病程、妄想或幻觉的存在与否或异常行为之间没有关联。这些结果支持了该异常的遗传基础。
