Burbaeva G Sh, Aksenova M V, Bibikova V I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(7):1024-8.
Creatine phosphokinase (CPK) activity has been determined in certain brain structures of schizophrenics and control subjects. It has been found that CPK activity in different structures of the normal human brain is heterogeneous, being the maximal in the occipital cortex (2.80 U/mg of protein) and thalamus (1.87 U/mg of protein) and the minimal in the temporal cortex (0.30 U/mg). In schizophrenic patients, CPK activity was significantly depressed (by 80-90%, P less than 0.001) in the occipital cortex and thalamus, as well as in the substantia nigra, limbic cortex and grey tuber (P less than 0.001) but remaining unaltered in the frontal, temporal and parietal cortex. It has been demonstrated that decrease in CPK activity does not depend on the post-mortem interval, sex and age of those examined or the psychotropic therapy conducted but appears to be related to a pathological process in the nervous tissue.
已对精神分裂症患者和对照受试者的某些脑结构中的肌酸磷酸激酶（CPK）活性进行了测定。已发现，正常人大脑不同结构中的CPK活性是异质的，在枕叶皮质（2.80 U/mg蛋白质）和丘脑（1.87 U/mg蛋白质）中最高，在颞叶皮质中最低（0.30 U/mg）。在精神分裂症患者中，枕叶皮质、丘脑以及黑质、边缘皮质和灰结节中的CPK活性显著降低（降低80 - 90%，P小于0.001），但额叶、颞叶和顶叶皮质中的CPK活性保持不变。已证明CPK活性的降低不取决于死后间隔时间、受检者的性别和年龄或所进行的精神药物治疗，而是似乎与神经组织中的病理过程有关。
