School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil.
Department of Biological Sciences, University of Worcester, Henwick Grove, Worcester WR2 6AJ, United Kingdom.
Pharmacol Res. 2018 Nov;137:170-178. doi: 10.1016/j.phrs.2018.10.007. Epub 2018 Oct 9.
Cardiovascular disease is a highly prevalent issue worldwide, and one of its main manifestations, dyslipidaemia, needs more attention. Cooked artichoke (Cynara scolymus) hearts or artichoke leaf extract (ALE) are believed to be helpful in the treatment of dyslipidaemia. In this narrative review, we provide a brief overview of the potential impact of artichoke consumption on lipid profile. We appraised the Cochrane, MEDLINE and Web of Science databases, and included articles published between 2000 and June 2018 on intervention in humans only. The main potential of ALE administration observed on lipid profile relates to decreased serum LDL, total cholesterol and triglyceride concentrations, although no strong evidence for increasing HDL appears to exist. Evidence suggests that decreases of 8-49 mg/dL for LDL concentration, 12-55 mg/dL for total cholesterol, and 11-51 mg/dL for triglycerides, can be attributed to 2 to 3 g/d of ALE, in which its components luteolin and chlorogenic acid may play a key role. On the other hand, the effects of cooked artichoke hearts can be attributed mainly to its soluble fibres, particularly inulin. Despite the convincing evidence on its health benefits, additional long-term clinical trials are pivotal to fully elucidate the potential effects of ALE administration on positive cardiovascular outcomes.
心血管疾病是全球高发疾病之一，其主要表现之一血脂异常需要更多关注。烹饪后的朝鲜蓟（朝鲜蓟）心或朝鲜蓟叶提取物（ALE）被认为有助于治疗血脂异常。在这篇叙述性综述中，我们简要概述了朝鲜蓟消费对血脂谱的潜在影响。我们评估了 Cochrane、MEDLINE 和 Web of Science 数据库，并仅纳入了 2000 年至 2018 年 6 月期间关于人类干预的文章。ALE 给药对血脂谱的主要潜在影响与血清 LDL、总胆固醇和甘油三酯浓度降低有关，尽管似乎没有强有力的证据表明 HDL 会增加。有证据表明，ALA 每天 2 至 3 克可使 LDL 浓度降低 8-49mg/dL、总胆固醇降低 12-55mg/dL、甘油三酯降低 11-51mg/dL，其成分叶黄素和绿原酸可能发挥关键作用。另一方面，烹饪后的朝鲜蓟心的作用主要归因于其可溶性纤维，特别是菊粉。尽管有令人信服的健康益处证据，但还需要更多的长期临床试验来充分阐明 ALE 给药对心血管阳性结果的潜在影响。
