Crespi Bernard, Read Silven, Hurd Peter
Department of Biological Sciences, 8888 University Drive, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Department of Biological Sciences, 8888 University Drive, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Brain Lang. 2017 Oct;173:33-40. doi: 10.1016/j.bandl.2017.06.002. Epub 2017 Jun 10.
We genotyped a healthy population for three haplotype-tagging FOXP2 SNPs, and tested for associations of these SNPs with strength of handedness and questionnaire-based metrics of inner speech characteristics (ISP) and speech fluency (FLU), as derived from the Schizotypal Personality Questionnaire-BR. Levels of mixed-handedness were positively correlated with ISP and FLU, supporting prior work on these two domains. Genotype for rs7799109, a SNP previously linked with lateralization of left frontal regions underlying language, was associated with degree of mixed handedness and with scores for ISP and FLU phenotypes. Genotype of rs1456031, which has previously been linked with auditory hallucinations, was also associated with ISP phenotypes. These results provide evidence that FOXP2 SNPs influence aspects of human inner speech and fluency that are related to lateralized phenotypes, and suggest that the evolution of human language, as mediated by the adaptive evolution of FOXP2, involved features of inner speech.
我们对一组健康人群进行了三种单倍型标签FOXP2单核苷酸多态性（SNP）的基因分型，并测试了这些SNP与利手强度以及基于问卷的内心言语特征（ISP）和言语流畅性（FLU）指标之间的关联，这些指标来自分裂型人格问卷 - 巴西版。混合利手水平与ISP和FLU呈正相关，支持了此前在这两个领域的研究工作。rs7799109这一单核苷酸多态性先前与语言相关的左额叶区域的偏侧化有关，其基因型与混合利手程度以及ISP和FLU表型得分相关。rs1456031的基因型先前与幻听有关，它也与ISP表型相关。这些结果提供了证据，表明FOXP2单核苷酸多态性影响与偏侧化表型相关的人类内心言语和流畅性方面，并表明由FOXP2的适应性进化介导的人类语言进化涉及内心言语的特征。
