Song Yaling, Zhou Jianming, Wang Xuejing, Xie Xue, Zhao Yiwu, Ni Fuyong, Huang Wenzhe, Wang Zhenzhong, Xiao Wei
a Jiangsu Kanion Pharmaceutical Co., Ltd. , Lianyungang , People's Republic of China.
b State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process , Lianyungang , People's Republic of China.
Nat Prod Res. 2018 Jan;32(1):77-84. doi: 10.1080/14786419.2017.1335724. Epub 2017 Jun 14.
A new ferulic acid ester, 6-feruloyloxyhexanoic acid (1), was isolated along with 10 known ones (2-11), from the concentrated water extract of Rhodiola wallichiana var. cholaensis. Their chemical structures were elucidated on the basis of extensive spectroscopic methods including Two-dimensional nuclear magnetic resonance (2D NMR) experiments. Compound 3 was isolated from this plant for the first time. The protective effects against HO-induced myocardial cell injury in cultured H9c2 cells were also evaluated. Compounds 1, 5 and 7-11 provided significant protective effects on HO-induced H9c2 cells injury at the concentration of 25 μg/mL. And the protective effects of compound 1 was also investigated by the oxygen-glucose deprivation/reperfusion (OGD/R) tests.
从长鞭红景天变种乔松的浓缩水提取物中分离出一种新的阿魏酸酯，6-阿魏酰氧基己酸（1），以及10种已知化合物（2-11）。通过包括二维核磁共振（2D NMR）实验在内的广泛光谱方法阐明了它们的化学结构。化合物3首次从该植物中分离得到。还评估了其对培养的H9c2细胞中HO诱导的心肌细胞损伤的保护作用。化合物1、5和7-11在浓度为25μg/mL时对HO诱导的H9c2细胞损伤具有显著的保护作用。并且通过氧糖剥夺/再灌注（OGD/R）试验研究了化合物1的保护作用。
