Zhang Jun-Liang, Yan Ren-Jie, Yu Ning, Zhang Xue, Chen Dai-Jie, Wu Tong, Xin Jian-Guo
a State Key Laboratory of New Drug & Pharmaceutical Process , Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry , Shanghai , PR China.
b Xinjiang Key Laboratory of Uighur Medicines , Xinjiang Institute of Materia Medica , Urumqi , PR China.
Nat Prod Res. 2018 Feb;32(3):370-373. doi: 10.1080/14786419.2017.1359168. Epub 2017 Aug 14.
A new caffeic acid tetramer compound, named (+) methyl rabdosiin (4), together with seven known caffeic acid multimers (1-3, 5-8) and one caffeic acid monomer (9), were isolated from the aerial parts of Dracocephalum moldavica L. The structures of these compounds were assigned on the basis of 1D and 2D NMR spectroscopic and mass spectrometry analyses. The protective effects of compounds 2-4 against hydrogen peroxide (HO)-induced apoptosis were evaluated in primary cardiomyocytes of SD neonatal rats in vitro by the MTT method. Three compounds exhibited potent protective activities at 12.5 μg/mL.
从香青兰地上部分分离得到一种新的咖啡酸四聚体化合物，命名为(+) - 甲基香茶菜素(4)，以及七种已知的咖啡酸多聚体(1 - 3, 5 - 8)和一种咖啡酸单体(9)。这些化合物的结构通过一维和二维核磁共振光谱及质谱分析确定。采用MTT法在体外对SD新生大鼠原代心肌细胞中化合物2 - 4抗过氧化氢(H₂O₂)诱导的细胞凋亡的保护作用进行了评价。三种化合物在12.5μg/mL时表现出较强的保护活性。
