Mertsola J
Eur J Clin Microbiol. 1985 Apr;4(2):123-8. doi: 10.1007/BF02013576.
The epidemiology of whooping cough in a vaccinated population was studied during an outbreak of paroxysmal cough in an elementary school with 258 pupils in Turku, Finland. Nasopharyngeal specimens for isolation of Bordetella pertussis and/or sera for ELISA detection of antipertussis immunoglobulin M, A and G antibodies were taken from 94% of children who were prospectively followed for two months. Bordetella pertussis was isolated in six patients, and 17 culture-positive cases with Bordetella parapertussis were identified. Patients with Bordetella pertussis or Bordetella parapertussis were found simultaneously in the same classrooms. Comparison of immunoglobulin M responses to Bordetella pertussis and Bordetella parapertussis was used for differential diagnosis of these two infections. Twenty-six cases with pertussis and 27 cases with parapertussis were diagnosed. The results of this prospective study suggest that Bordetella parapertussis is a more common etiologic agent of mild respiratory tract infection among vaccinated school-aged children than is generally recognised. The possibility that Bordetella pertussis was converted to Bordetella parapertussis during this outbreak is discussed.
在芬兰图尔库一所拥有258名学生的小学发生阵发性咳嗽疫情期间，对疫苗接种人群中的百日咳流行病学进行了研究。对前瞻性随访两个月的94%的儿童采集了用于分离百日咳博德特氏菌的鼻咽标本和/或用于ELISA检测抗百日咳免疫球蛋白M、A和G抗体的血清。在6例患者中分离出百日咳博德特氏菌，鉴定出17例副百日咳博德特氏菌培养阳性病例。在同一教室中同时发现了感染百日咳博德特氏菌或副百日咳博德特氏菌的患者。通过比较对百日咳博德特氏菌和副百日咳博德特氏菌的免疫球蛋白M反应来对这两种感染进行鉴别诊断。确诊了26例百日咳病例和27例副百日咳病例。这项前瞻性研究的结果表明，在接种疫苗的学龄儿童中，副百日咳博德特氏菌是比普遍认识到的更为常见的轻度呼吸道感染病原体。讨论了在此次疫情期间百日咳博德特氏菌是否转变为副百日咳博德特氏菌的可能性。
