a Computational Modeling and Nano Scale Processing Unit , Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Government of India , Thanjavur , Tamil Nadu, India.
Nutr Cancer. 2018 Nov-Dec;70(8):1184-1198. doi: 10.1080/01635581.2018.1557212. Epub 2019 Feb 9.
At present, cancer is one of the major diseases in the world affecting numerous lives. There have been various approaches to combat the disease, particularly involving chemical interventions (chemotherapy). However, owing to serious side effects of chemotherapy, employment of natural supplements in cancer therapy has been long desired. Nutraceuticals are currently being studied as a medicament, to act as both preventive and curative measure. Nutraceuticals provide both nutrition and therapeutic benefits; besides, they are natural and biocompatible, and therefore pose no side effects. This facilitates their ready acceptance as dietary supplements with no requirements of special dosage and concerns over long-term usage. Nutraceuticals can be derived from the natural resources such as spices, fruits, vegetables, and plants. However, nutraceuticals are vulnerable to environmental stresses that necessitate encapsulation for long-term storage and required bioavailability. The review collates the findings on encapsulated nutraceuticals in liposomes for cancer therapy. The article provides a coherent overview of the research conducted on liposomal administration of nutraceuticals to target various forms of cancer, explaining the advances made.
目前，癌症是世界上主要的疾病之一，影响着众多生命。人们已经尝试了各种方法来对抗这种疾病，特别是涉及化学干预（化疗）。然而，由于化疗的严重副作用，人们长期以来一直希望在癌症治疗中使用天然补充剂。目前，正在研究营养保健品作为药物，既能起到预防作用，也能起到治疗作用。营养保健品既提供营养又提供治疗益处；此外，它们是天然的、生物相容的，因此没有副作用。这使得它们很容易被接受为膳食补充剂，不需要特殊的剂量和对长期使用的担忧。营养保健品可以从天然资源中提取，如香料、水果、蔬菜和植物。然而，营养保健品容易受到环境压力的影响，需要进行封装以实现长期储存和所需的生物利用度。本综述总结了关于脂质体包封营养保健品用于癌症治疗的研究结果。本文对营养保健品经脂质体给药靶向各种形式癌症的研究进行了综合概述，解释了所取得的进展。
