α-硫辛酸通过 NOX4、NF-κB、JNK 和 PI3K/AKT 通路对糖皮质激素诱导的骨质疏松症的成骨作用。
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
机构信息
Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Department of Orthopaedics, First Affiliated Hospital, Dalian Medical University, Dalian, China.
出版信息
Sci Rep. 2017 Jun 13;7(1):3331. doi: 10.1038/s41598-017-03187-w.
Recently, accumulating evidence has indicated that glucocorticoid-induced osteoporosis (GIOP) is closely related to oxidative stress and apoptosis. Alpha-lipoic acid (LA), a naturally endogenous anti-oxidant, possesses anti-oxidative and anti-apoptosis activities, implicating LA as a therapeutic agent for the treatment of GIOP. In this study, the osteogenesis-promoting effects of LA against GIOP were investigated and the mechanisms were further probed. Here, the results showed that LA inhibited oxidative stress, suppressed apoptosis and improved osteopenia by promoting the expression of osteogenesis markers, including ALP, COL-I, OCN, BMP-2, RUNX2 and OSX. Further study revealed that the osteogenesis-promoting effects of LA likely occur via the regulation of the NOX4, NF-kappaB, JNK and PI3K/AKT pathways. The present study indicated that LA may prevent GIOP and promote osteogenesis and might be a candidate for the treatment of GIOP.
最近的研究表明，糖皮质激素诱导性骨质疏松症（GIOP）与氧化应激和细胞凋亡密切相关。α-硫辛酸（LA）是一种天然的内源性抗氧化剂，具有抗氧化和抗凋亡作用，提示 LA 可能是治疗 GIOP 的一种治疗药物。在本研究中，研究了 LA 对 GIOP 的促骨生成作用，并进一步探讨了其机制。结果表明，LA 通过促进成骨标志物（包括 ALP、COL-I、OCN、BMP-2、RUNX2 和 OSX）的表达，抑制氧化应激，抑制细胞凋亡，改善骨质疏松症。进一步的研究表明，LA 的促骨生成作用可能是通过调节 NOX4、NF-κB、JNK 和 PI3K/AKT 通路实现的。本研究表明，LA 可能预防 GIOP 并促进成骨，可能是治疗 GIOP 的候选药物。
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