胰腺癌病因中的牙周病原体
Periodontal Pathogens in the Etiology of Pancreatic Cancer.
作者信息
Öğrendik Mesut
机构信息
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Uzunköprü State Hospital, Uzunköprü, Turkey.
出版信息
Gastrointest Tumors. 2017 Mar;3(3-4):125-127. doi: 10.1159/000452708. Epub 2016 Nov 25.
Abstract
BACKGROUND
Pancreatic cancer is the fourth leading cause of cancer-related deaths worldwide. Chronic pancreatitis is frequently observed in patients with pancreatic cancer, and a significant relationship between orodigestive cancer-related deaths and chronic periodontitis has been detected. , , and , collectively called the Red complex, are the major pathogens responsible for chronic periodontitis and secrete peptidylarginine deiminase. Anti- antibodies titers are higher in pancreatic cancer patients than in healthy subjects.
SUMMARY
This review examines the association between oral bacteria and the etiology of pancreatic cancer.
KEY MESSAGE
High rates of tumor suppressor gene mutations, particularly arginine mutations, were detected in pancreatic cancer patients. arginine mutations were detected in patients with pancreatic cancer. Oral bacteria peptidylarginine deiminases might lead to the and point mutations by degrading arginine.
PRACTICAL IMPLICATIONS
Oral bacteria are likely to be responsible for the development of pancreatic cancer. If this hypothesis is true, it may reveal the real cause of pancreatic cancer, which is a fatal disease.
摘要
背景
胰腺癌是全球癌症相关死亡的第四大主要原因。胰腺癌患者中经常观察到慢性胰腺炎，并且已检测到口腔消化道癌症相关死亡与慢性牙周炎之间存在显著关系。伴放线聚集杆菌、牙龈卟啉单胞菌和福赛坦氏菌统称为红色复合体，是导致慢性牙周炎的主要病原体，并分泌肽基精氨酸脱亚氨酶。胰腺癌患者中抗红色复合体抗体滴度高于健康受试者。
总结
本综述探讨口腔细菌与胰腺癌病因之间的关联。
关键信息
在胰腺癌患者中检测到肿瘤抑制基因突变率很高，尤其是精氨酸突变。在胰腺癌患者中检测到精氨酸突变。口腔细菌肽基精氨酸脱亚氨酶可能通过降解精氨酸导致密码子12和13的点突变。
实际意义
口腔细菌可能是胰腺癌发生的原因。如果这一假设成立，它可能揭示胰腺癌这一致命疾病的真正病因。
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