Trypanocidal action of and essential oils against in vitro and in vivo used mice as experimental model.

Parasitic diseases have an enormous health and economic impact and are a particular problem in tropical regions of the world. Disease caused by protozoa, such as trypanosomiasis, are the cause of most parasite related morbidity and mortality. Thus, the aim of this study was to verify the trypanocidal effectiveness of and against in vitro and in vivo and were used in vitro on trypomastigotes at different concentrations (0.5, 1.0 and 2.0 %) and exposure times (0, 1, 3, 6 and 9 h). The three concentrations tested showed trypanocidal activity in vitro, completely eliminating the parasites in small concentration after 6 h of assay. In vivo tests were performed using mice as the experimental model. infected mice were treated with and with dose of 1.5 mL kg during 5 days. These protocols did not provide curative efficacy, however the mice treated with showed a significant increase in the longevity when compared to control group. Active compounds present in essential oils, such as , may potentiate the treatment of trypanosomosis when associated with other trypanocidal drugs.