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这可能是一件大事的开端——自蝙蝠被确认为亨德拉病毒的自然宿主已有20年了。

This could be the start of something big-20 years since the identification of bats as the natural host of Hendra virus.

作者信息

Black Peter, Douglas Ian, Field Hume

机构信息

Essential Foresight, Canberra, ACT, Australia.

Food and Agricultural Organization of the United Nations, Rome, Italy.

出版信息

One Health. 2015 Aug 4;1:14-16. doi: 10.1016/j.onehlt.2015.07.001. eCollection 2015 Dec.

Abstract

Hendra virus was first described in 1994 in Australia, causally associated with a cluster of fatal equine and human cases at a thoroughbred racing stable in the Brisbane suburb of Hendra. This year marks the twentieth anniversary of the identification of pteropid bats (flying-foxes) as the natural host of the virus, and it is timely to reflect on a pivotal meeting of an eclectic group of scientists in that process. They included animal and public health experts, environmental scientists, veterinary and horse industry representatives, and wildlife experts. The task was to review and prioritise wildlife surveillance seeking the origin of the previously unknown virus. The group determined that the likely reservoir must occur in disparate locations, and be capable of moving between locations, or exist in continuous, overlapping populations spanning multiple locations. Flying-foxes were considered to be a more probable source of the novel virus than birds. Within weeks, antibodies were detected in several species of flying-fox, and the virus was subsequently isolated. While the identification of the natural host of Hendra virus within 18 months of its description was remarkable in itself, a broader legacy followed. In the subsequent years, a suite of zoonotic viruses including Australian bat lyssavirus, Nipah virus, SARS coronavirus, and Ebola and Marburg viruses have been detected in bats. Bats are now the "go to" taxa for novel viruses. History has repeatedly demonstrated that knowledge begets knowledge. This simple notion of bringing a diverse group of people together in an environment of mutual respect reinforced this principle and proves that the sum is often so much more powerful than the parts.

摘要

亨德拉病毒于1994年在澳大利亚首次被发现,与布里斯班郊区亨德拉的一个纯种赛马场发生的一系列致命的马和人感染病例有因果关系。今年是将狐蝠确定为该病毒自然宿主20周年,回顾一下在这一过程中一群 eclectic 科学家召开的一次关键会议很有必要。他们包括动物和公共卫生专家、环境科学家、兽医和马匹行业代表以及野生动物专家。任务是审查野生动物监测情况并确定寻找这种此前未知病毒来源的优先事项。该小组确定,可能的宿主必须分布在不同地点,并且能够在不同地点之间移动,或者存在于跨越多个地点的连续、重叠种群中。狐蝠被认为比鸟类更有可能是这种新型病毒的来源。几周内,在几种狐蝠中检测到了抗体,随后分离出了病毒。虽然在描述亨德拉病毒后的18个月内就确定了其天然宿主本身就很了不起,但随后还有更广泛的影响。在随后的几年里,在蝙蝠中检测到了一系列人畜共患病毒,包括澳大利亚蝙蝠狂犬病毒、尼帕病毒、SARS冠状病毒以及埃博拉病毒和马尔堡病毒。蝙蝠现在成了新型病毒的“首选”类群。历史一再证明,知识产生知识。在相互尊重的环境中让一群不同的人聚在一起这个简单的理念强化了这一原则,并证明整体往往比部分强大得多。

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本文引用的文献

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Bats and viruses: friend or foe?蝙蝠与病毒:敌还是友?
PLoS Pathog. 2013 Oct;9(10):e1003651. doi: 10.1371/journal.ppat.1003651. Epub 2013 Oct 31.
2
Bats: important reservoir hosts of emerging viruses.蝙蝠:新兴病毒的重要宿主
Clin Microbiol Rev. 2006 Jul;19(3):531-45. doi: 10.1128/CMR.00017-06.
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Fer de Lance virus (FDLV): a probable paramyxovirus isolated from a reptile.
J Gen Virol. 1979 Aug;44(2):405-18. doi: 10.1099/0022-1317-44-2-405.

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