Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Am J Med Genet A. 2010 Jan;152A(1):147-52. doi: 10.1002/ajmg.a.33193.
Recent studies have shown that individuals with schizophrenia and their family members are interested in genetic counseling, but few have received this service. We conducted an exploratory, retrospective study to describe (a) the population of individuals who were referred to the BC provincial medical genetics program for genetic counseling for a primary indication of schizophrenia, and (b) trends in number of referrals between 1968 and 2007. Referrals for a primary indication of schizophrenia were identified through the provincial program database. Charts were reviewed and the following information was recorded: discipline of referring physician, demographics, psychiatric diagnosis, referred individual's and partner's (if applicable) family history, and any current pregnancy history. Data were characterized using descriptive statistics. Our results showed that between 1968 and 2007, 288 referrals were made for a primary indication of schizophrenia. Most referrals were made: (a) for individuals who had a first-degree family member with schizophrenia, rather than for affected individuals, (b) for preconception counseling, and (c) by family physicians (69%), with only 2% by psychiatrists. In conclusion, for British Columbia, individuals affected with schizophrenia and their family members are rarely referred for psychiatric genetic counseling. There is a need to identify barriers to psychiatric genetic counseling and develop strategies to improve access.
最近的研究表明，精神分裂症患者及其家属对遗传咨询感兴趣，但很少有人接受过这项服务。我们进行了一项探索性的回顾性研究，以描述：（a）因主要精神分裂症指征而被转介到不列颠哥伦比亚省医学遗传学项目接受遗传咨询的人群；（b）1968 年至 2007 年间转介人数的趋势。通过省级项目数据库确定了因主要精神分裂症指征而转介的情况。我们对图表进行了审查，并记录了以下信息：转介医生的学科、人口统计学特征、精神科诊断、转介者及其伴侣（如适用）的家族史，以及任何当前的妊娠史。数据使用描述性统计进行了描述。我们的研究结果表明，1968 年至 2007 年间，有 288 例因主要精神分裂症指征而转介。大多数转介情况为：（a）针对有一级亲属患有精神分裂症的个体，而非针对受影响的个体，（b）进行受孕前咨询，（c）由家庭医生（69%）进行，而只有 2%由精神科医生进行。总之，对于不列颠哥伦比亚省来说，患有精神分裂症的个体及其家属很少被转介接受精神科遗传咨询。有必要确定精神科遗传咨询的障碍，并制定改善获取途径的策略。
