具有合成纳米级糖材料的糖萼支架
Glycocalyx scaffolding with synthetic nanoscale glycomaterials.
作者信息
Huang Mia L, Purcell Sean C, Verespy Stephen, Wang Yinan, Godula Kamil
机构信息
Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, MC 0358, La Jolla, CA, USA.
出版信息
Biomater Sci. 2017 Jul 25;5(8):1537-1540. doi: 10.1039/c7bm00289k.
Abstract
We report a method for programming complexity into the glycocalyx of live cells. Via a combination of glycomaterial synthesis and membrane remodeling, we have engineered cells to display native-like, mixed sialoglycan populations, while confining the activity of each glycan into a specific nanoscale presentation.
摘要
我们报告了一种将复杂性编程到活细胞糖萼中的方法。通过糖材料合成和膜重塑相结合，我们对细胞进行了工程改造，使其呈现出类似天然的混合唾液酸聚糖群体，同时将每种聚糖的活性限制在特定的纳米级呈现中。
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