Alano Pietro
Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy.
Ann Ist Super Sanita. 2017 Apr-Jun;53(2):96-99. doi: 10.4415/ANN_17_02_03.
The spread of malaria relies on the ability of the Plasmodium parasites to be transmitted from infected individuals to the Anopheles mosquito vectors. Recent work on the most lethal of the malaria parasites, Plasmodium falciparum, identified the infected human bone marrow as a preferential site for the localization and maturation of the parasite transmission stages, the gametocytes. These findings unveil a complex host parasite interplay and an unsuspected role of the bone marrow microenvironment in the successful transmission of the malaria parasite and have major implications in developing and targeting future interventions to block the transmission of P. falciparum.
疟疾的传播依赖于疟原虫从受感染个体传播到按蚊媒介的能力。最近针对最致命的疟原虫——恶性疟原虫开展的研究，确定受感染人类骨髓是疟原虫传播阶段（即配子体）定位和成熟的优先部位。这些发现揭示了宿主与寄生虫之间复杂的相互作用，以及骨髓微环境在疟原虫成功传播中所起的意想不到的作用，对开发和靶向未来阻断恶性疟原虫传播的干预措施具有重要意义。
