骨髓的血管外腔隙：恶性疟原虫配子体成熟的小生境？
The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?
机构信息
Laboratoire de parasitologie-mycologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.
出版信息
Malar J. 2012 Aug 20;11:285. doi: 10.1186/1475-2875-11-285.
BACKGROUND
Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear.
METHODS
The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria.
RESULTS
A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces.
DISCUSSION AND CONCLUSION
These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.
背景
恶性疟原虫未成熟配子体在骨髓中积累，但它们在该组织中的确切位置尚不清楚。
方法
对 1 例亚急性恶性疟患者骨髓样本的组织切片进行分析，研究配子体的阶段和沉积模式。
结果
在外周血管间隙中观察到大多数（89%）处于 II 期到 IV 期的未成熟阶段和少数（29%）处于 V 期的成熟阶段的配子体。
讨论和结论
这些观察结果是了解恶性疟原虫配子体隔离模式的重要一步，最终可能导致新的传播阻断干预措施。
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