Joice Regina, Nilsson Sandra K, Montgomery Jacqui, Dankwa Selasi, Egan Elizabeth, Morahan Belinda, Seydel Karl B, Bertuccini Lucia, Alano Pietro, Williamson Kim C, Duraisingh Manoj T, Taylor Terrie E, Milner Danny A, Marti Matthias
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Malawi-Liverpool-Wellcome Trust Clinical Research Programme, P. O. Box 30096, Chichiri, Blantyre 3, Malawi. Liverpool School of Tropical Medicine, University of Liverpool, Liverpool L3 5QA, UK.
Sci Transl Med. 2014 Jul 9;6(244):244re5. doi: 10.1126/scitranslmed.3008882.
Transmission of Plasmodium falciparum malaria parasites requires formation and development of gametocytes, yet all but the most mature of these sexual parasite forms are absent from the blood circulation. We performed a systematic organ survey in pediatric cases of fatal malaria to characterize the spatial dynamics of gametocyte development in the human host. Histological studies revealed a niche in the extravascular space of the human bone marrow where gametocytes formed in erythroid precursor cells and underwent development before reentering the circulation. Accumulation of gametocytes in the hematopoietic system of human bone marrow did not rely on cytoadherence to the vasculature as does sequestration of asexual-stage parasites. This suggests a different mechanism for the sequestration of gametocytes that could potentially be exploited to block malaria transmission.
恶性疟原虫疟原虫的传播需要配子体的形成和发育，然而，除了最成熟的这些有性寄生虫形式外，血液循环中几乎不存在其他形式。我们对致命疟疾的儿科病例进行了系统的器官调查，以描述人类宿主中配子体发育的空间动态。组织学研究揭示了人类骨髓血管外空间中的一个生态位，配子体在红细胞前体细胞中形成，并在重新进入循环之前在此处发育。人类骨髓造血系统中配子体的积累并不像无性阶段寄生虫的滞留那样依赖于对脉管系统的细胞粘附。这表明存在一种不同的配子体滞留机制，有可能被利用来阻断疟疾传播。
