Ording H, Skovgaard L T, Engbaek J, Viby-Mogensen J
Acta Anaesthesiol Scand. 1985 Jan;29(1):121-4. doi: 10.1111/j.1399-6576.1985.tb02171.x.
The purpose of this study was to compare the incremental, cumulative dose method and the single bolus injection technique for construction of dose-response curves for vecuronium. Dose-response curves were determined in 77 patients divided into four groups according to the anaesthetic given and the method used for construction of dose-response curves. The regression lines corresponding to the four dose-response curves were found to be parallel. For vecuronium ED50 during neurolept anaesthesia was found to be 28 micrograms kg-1 with the single bolus injection technique and 35.2 micrograms kg-1 with the incremental, cumulative dose method (P less than 0.05). During halothane anaesthesia, ED50 was found to be 25.7 micrograms kg-1 and 26.2 micrograms kg-1, respectively (P greater than 0.05). Potentiation of vecuronium by halothane was found with the cumulative method only. It is concluded that the incremental, cumulative dose method is not suitable for potency determinations of vecuronium.
本研究旨在比较维库溴铵剂量-反应曲线构建中的递增累积剂量法和单次推注技术。根据所给予的麻醉方式和构建剂量-反应曲线所采用的方法，将77例患者分为四组并测定其剂量-反应曲线。发现对应四条剂量-反应曲线的回归线相互平行。在神经安定麻醉期间，采用单次推注技术时维库溴铵的半数有效剂量（ED50）为28微克/千克，采用递增累积剂量法时为35.2微克/千克（P<0.05）。在氟烷麻醉期间，ED50分别为25.7微克/千克和26.2微克/千克（P>0.05）。仅在累积法中发现氟烷对维库溴铵有增强作用。得出的结论是，递增累积剂量法不适用于维库溴铵效能的测定。
