Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.
Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland; Center for Complementary and Integrative Medicine, University Hospital Zurich, Zurich, Switzerland.
Biol Psychiatry. 2017 Sep 15;82(6):421-430. doi: 10.1016/j.biopsych.2017.05.012. Epub 2017 May 25.
This article outlines how a core concept from theories of homeostasis and cybernetics, the inference-control loop, may be used to guide differential diagnosis in computational psychiatry and computational psychosomatics. In particular, we discuss 1) how conceptualizing perception and action as inference-control loops yields a joint computational perspective on brain-world and brain-body interactions and 2) how the concrete formulation of this loop as a hierarchical Bayesian model points to key computational quantities that inform a taxonomy of potential disease mechanisms. We consider the utility of this perspective for differential diagnosis in concrete clinical applications.
本文概述了来自内稳态和控制论理论的核心概念——推理控制回路，如何用于指导计算精神病学和计算身心医学中的鉴别诊断。具体而言，我们讨论了：1）将感知和行动概念化为推理控制回路，为大脑-世界和大脑-身体相互作用提供了联合计算视角；2）该回路的具体分层贝叶斯模型公式，为潜在疾病机制的分类提供了关键的计算量。我们考虑了这种观点在具体临床应用中的鉴别诊断的效用。
