Rich Peter R
Glynn Laboratory of Bioenergetics, Institute of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Biochem Soc Trans. 2017 Jun 15;45(3):813-829. doi: 10.1042/BST20160139.
Mitochondrial cytochrome oxidase is a member of a diverse superfamily of haem-copper oxidases. Its mechanism of oxygen reduction is reviewed in terms of the cycle of catalytic intermediates and their likely chemical structures. This reaction cycle is coupled to the translocation of protons across the inner mitochondrial membrane in which it is located. The likely mechanism by which this occurs, derived in significant part from studies of bacterial homologues, is presented. These mechanisms of catalysis and coupling, together with current alternative proposals of underlying mechanisms, are critically reviewed.
线粒体细胞色素氧化酶是血红素-铜氧化酶这一多样超家族的成员之一。本文根据催化中间体的循环及其可能的化学结构，对其氧还原机制进行了综述。该反应循环与质子跨其所在的线粒体内膜的转运相偶联。文中介绍了这一过程可能的机制，这在很大程度上源于对细菌同源物的研究。对这些催化和偶联机制，以及当前关于潜在机制的其他提议进行了批判性综述。
