Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):a028522. doi: 10.1101/cshperspect.a028522.
The cytokines of the interleukin 17 (IL-17) family play a central role in the control of infections, especially extracellular fungi. Conversely, if unrestrained, these inflammatory cytokines contribute to the pathology of numerous autoimmune and chronic inflammatory conditions. Recent advances have led to the approval of IL-17A-blocking biologics for the treatment of moderate to severe plaque psoriasis, but much remains to be understood about the biological functions, regulation, and signaling pathways downstream of these factors. In this review, we outline the current knowledge of signal transduction and known physiological activities of IL-17 family cytokines. We will highlight in particular the current understanding of these cytokines in the context of skin manifestations of disease.
白细胞介素 17（IL-17）家族的细胞因子在感染的控制中起着核心作用，尤其是对细胞外真菌。相反，如果不受控制，这些炎症细胞因子会导致许多自身免疫和慢性炎症疾病的病理发生。最近的进展导致了 IL-17A 阻断生物制剂的批准，用于治疗中重度斑块状银屑病，但对于这些因子的下游生物学功能、调节和信号转导仍有许多需要了解的地方。在这篇综述中，我们概述了目前对信号转导和 IL-17 家族细胞因子已知生理活性的认识。我们将特别强调目前对这些细胞因子在疾病皮肤表现中的理解。
