Smith Terry K, Bringaud Frédéric, Nolan Derek P, Figueiredo Luisa M
Biomedical Sciences Research Complex, University of St Andrews, Fife, UK.
Laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234 CNRS, Université de Bordeaux, Bordeaux, France.
F1000Res. 2017 May 16;6. doi: 10.12688/f1000research.10342.2. eCollection 2017.
Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The causative agent of sleeping sickness, , is an exclusively extracellular protozoan parasite that encounters very different extracellular environments during its life cycle within the mammalian host and tsetse fly insect vector. In order to meet these challenges, there are significant alterations in the major energetic and metabolic pathways of these highly adaptable parasites. This review highlights some of these metabolic changes in this early divergent eukaryotic model organism.
细胞代谢活动是一个高度复杂、动态且受调控的过程，受到众多因素的影响，包括细胞外环境信号、营养物质的可利用性以及细胞的生理和发育状态。昏睡病的病原体布氏锥虫是一种专性细胞外原生动物寄生虫，在其于哺乳动物宿主和采采蝇昆虫媒介体内的生命周期中，会遇到截然不同的细胞外环境。为了应对这些挑战，这些高度适应性的寄生虫的主要能量和代谢途径发生了显著变化。本综述重点介绍了这种早期分化的真核模式生物中的一些代谢变化。
