从巴基斯坦种植的长春花中分离出的三种新吡啶生物碱。

Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan.

作者信息

Wei Xin, Khan Afsar, Song Da, Dai Zhi, Liu Ya-Ping, Yu Hao-Fei, Wang Bei, Zhu Pei-Feng, Ding Cai-Feng, Zhao Xu-Dong, Wang Yi-Fen, Luo Xiao-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.

University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2017 Aug;7(4):323-327. doi: 10.1007/s13659-017-0137-7. Epub 2017 Jun 15.

DOI:10.1007/s13659-017-0137-7

PMID:28620872

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5507811/

Abstract

Three new pyridine type alkaloids, (-)-vinmajpyridines A-C (1-3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3 and GITC-18), glioblastoma cell lines (U-87MG and T98G), and lung cancer cell line A-549, but none of them was active at 20 μg/mL concentration.

摘要

从巴基斯坦种植的长春花地上部分分离出三种新的吡啶类生物碱，(-)-长春马吡啶A-C（1-3），以及两种已知生物碱。它们的结构已通过核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）光谱数据得以阐明。对这些新生物碱针对胶质瘤起始细胞系（GITC-3和GITC-18）、胶质母细胞瘤细胞系（U-87MG和T98G）以及肺癌细胞系A-549进行了细胞毒性评估，但在20μg/mL浓度下它们均无活性。