长春花的非生物碱成分。
Non-alkaloid constituents of Vinca major.
作者信息
Cheng Gui-Guang, Zhao Hai-Yun, Liu Lu, Zhao Yun-Li, Song Chang-Wei, Gu Ji, Sun Wei-Bang, Liu Ya-Ping, Luo Xiao-Dong
机构信息
Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, 650500, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, 650500, China.
出版信息
Chin J Nat Med. 2016 Jan;14(1):56-60. doi: 10.3724/SP.J.1009.2016.00056.
The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination with UV, IR, and MS analyses. The 1, 1-diphenyl-2-picrylhydrazyl (DPPH)-scavenging activity of Compounds 1-7 were evaluated. One new iridoid glycoside (compound 1), together with 11 known compounds, were isolated from Vinca major. Compounds 1, 5, and 6 showed moderate DPPH-scavenging activity, with IC50 values being 70.6, 32.8, and 62.2 μmol·L(-1), respectively. In conclusion, compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity.
本研究旨在对中国云南省种植的长春花的叶和茎中的非生物碱化合物进行研究。采用色谱技术分离这些化合物。通过一维和二维核磁共振光谱方法结合紫外、红外和质谱分析来阐明其结构。评估了化合物1 - 7对1,1 - 二苯基 - 2 - 苦基肼（DPPH）的清除活性。从长春花中分离出一种新的环烯醚萜苷（化合物1）以及11种已知化合物。化合物1、5和6表现出中等的DPPH清除活性，IC50值分别为70.6、32.8和62.2 μmol·L(-1)。总之，化合物1是一种新鉴定的具有中等抗氧化活性的环烯醚萜苷。
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