基因表达调控中的动态RNA修饰
Dynamic RNA Modifications in Gene Expression Regulation.
作者信息
Roundtree Ian A, Evans Molly E, Pan Tao, He Chuan
机构信息
Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57(th) Street, Chicago, IL 60637, USA; Medical Scientist Training Program, The University of Chicago, 924 East 57(th) Street, Chicago, IL 60637, USA.
Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57(th) Street, Chicago, IL 60637, USA.
出版信息
Cell. 2017 Jun 15;169(7):1187-1200. doi: 10.1016/j.cell.2017.05.045.
Over 100 types of chemical modifications have been identified in cellular RNAs. While the 5' cap modification and the poly(A) tail of eukaryotic mRNA play key roles in regulation, internal modifications are gaining attention for their roles in mRNA metabolism. The most abundant internal mRNA modification is N-methyladenosine (mA), and identification of proteins that install, recognize, and remove this and other marks have revealed roles for mRNA modification in nearly every aspect of the mRNA life cycle, as well as in various cellular, developmental, and disease processes. Abundant noncoding RNAs such as tRNAs, rRNAs, and spliceosomal RNAs are also heavily modified and depend on the modifications for their biogenesis and function. Our understanding of the biological contributions of these different chemical modifications is beginning to take shape, but it's clear that in both coding and noncoding RNAs, dynamic modifications represent a new layer of control of genetic information.
细胞RNA中已鉴定出100多种化学修饰类型。虽然真核mRNA的5'帽修饰和多聚腺苷酸尾在调控中起关键作用，但内部修饰因其在mRNA代谢中的作用而受到关注。最丰富的内部mRNA修饰是N-甲基腺苷（mA），对安装、识别和去除这种修饰及其他标记的蛋白质的鉴定揭示了mRNA修饰在mRNA生命周期的几乎每个方面以及各种细胞、发育和疾病过程中的作用。丰富的非编码RNA，如tRNA、rRNA和剪接体RNA，也有大量修饰，并且其生物发生和功能依赖于这些修饰。我们对这些不同化学修饰的生物学贡献的理解正在形成，但很明显，在编码和非编码RNA中，动态修饰代表了遗传信息控制的一个新层面。
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