Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of Sao Paulo (UNIFESP) and Vision Institute, São Paulo, São Paulo, Brazil; Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of Sao Paulo (UNIFESP) and Vision Institute, São Paulo, São Paulo, Brazil; Altino Ventura Foundation (FAV), Recife, Pernambuco, Brazil.
Surv Ophthalmol. 2018 Mar-Apr;63(2):166-173. doi: 10.1016/j.survophthal.2017.06.001. Epub 2017 Jun 13.
Zika virus was considered an innocent pathogen while restricted to the African and Asian population; however, after reaching the Americas in March 2015, it became a global threat. Despite usually causing mild or no symptoms in infected adults, Zika virus displays a different behavior toward fetuses. When infected during gestation, fetuses have their immature neural cells killed by the virus and consequently have devastating findings at birth. In the past year the drastic effects of Zika virus infection in newborns include neurological, ophthalmological, audiological, and skeletal abnormalities. These findings represent a new entity called congenital Zika syndrome. We summarize the ocular findings of congenital Zika Syndrome, as well as the current understanding of the illness, systemic manifestations, laboratory investigation, differential diagnosis, prophylaxis, and treatment for this disorder.
寨卡病毒被认为是一种无害的病原体，局限于非洲和亚洲人群；然而，2015 年 3 月到达美洲后，它成为了一种全球威胁。尽管寨卡病毒通常在感染的成年人中引起轻微或无症状，但它对胎儿的表现却不同。当孕妇在妊娠期间感染时，胎儿不成熟的神经细胞会被病毒杀死，因此在出生时会有严重的发现。在过去的一年中，寨卡病毒感染对新生儿的影响包括神经、眼科、听力和骨骼异常。这些发现代表了一种称为先天性寨卡综合征的新实体。我们总结了先天性寨卡综合征的眼部表现，以及目前对这种疾病的理解、全身表现、实验室检查、鉴别诊断、预防和治疗。
