Rakhypbekov Tolebay, Inoue Ken, Pak Laura, Kawano Noriyuki, Takeichi Nobuo, Hoshi Masaharu, Noso Yoshihiro, Chaizhunusova Nailya, Manambayeva Zukhra, Khozhayev Arman, Molgazhdarov Maulen, Olzhaev Sayakhat, Tokanova Sholpan, Madiyeva Madina
Semey State Medical University, Abay Str. 103, Semey, 071400, Kazakhstan.
Health Service Center, Kochi University, 2-5-1, Akebono-cho, Kochi-shi, Kochi, 780-8520, Japan.
Radiat Environ Biophys. 2017 Aug;56(3):205-211. doi: 10.1007/s00411-017-0695-4. Epub 2017 Jun 16.
We sought to identify the features of endothelial function in rectal cancer patients who were exposed to chronic ionizing radiation from a nuclear test site in Kazakhstan. We examined 146 individuals, 76 of whom were rectal cancer patients. The existence of a complex of disturbances of the endothelium and hemostasis systems in patients vs non-patients was revealed. Endothelial dysfunction was expressed as an increase of nitric oxide (NO) production along with decreases in vasodilatation function, and increased levels of von Willebrand factor in blood, along with an increase in the number of circulating endotheliocytes. Significant correlations between indicators of endothelial function and vascular-platelet hemostasis were observed. These changes and their interrelations were expressed more strongly in the patients who lived in the contaminated area around the nuclear test site. Such patients could have an increased risk of thrombosis and other complications after the treatment of a malignant neoplasm.
我们试图确定接触来自哈萨克斯坦核试验场慢性电离辐射的直肠癌患者的内皮功能特征。我们检查了146人，其中76人是直肠癌患者。结果显示患者与非患者相比存在内皮和止血系统的一系列紊乱。内皮功能障碍表现为一氧化氮（NO）生成增加，同时血管舒张功能降低，血液中血管性血友病因子水平升高，以及循环内皮细胞数量增加。观察到内皮功能指标与血管血小板止血之间存在显著相关性。这些变化及其相互关系在居住在核试验场周边污染地区的患者中表现得更为强烈。这类患者在恶性肿瘤治疗后可能有血栓形成及其他并发症的风险增加。
