Avagliano Laura, Massa Valentina, Terraneo Laura, Samaja Michele, Doi Patrizia, Bulfamante Gaetano Pietro, Marconi Anna Maria
Department of Health Sciences, San Paolo Hospital Medical School University of Milan, Milan, Italy.
Department of Health Sciences, San Paolo Hospital Medical School University of Milan, Milan, Italy.
Placenta. 2017 Jul;55:90-93. doi: 10.1016/j.placenta.2017.05.002. Epub 2017 May 15.
Autophagy is a catabolic process involved in the preservation of energy homeostasis and its dysregulation has been implicated in the development of metabolic disorders, including diabetes mellitus. Gestational diabetes mellitus represents a risk for fetal morbidity and mortality. The present study focuses on the autophagy process in human diabetic placenta and fetal pancreas, compared with controls. Analysis of the autophagy markers LC3, Beclin-1 and p62 suggests an impairment of the autophagy process in diabetic placentas. Results indicate an association between gestational diabetes and autophagy, emphasizing the importance of unravelling the mechanisms regulating this relationship.
自噬是一种分解代谢过程，参与能量稳态的维持，其失调与包括糖尿病在内的代谢紊乱的发生有关。妊娠期糖尿病是胎儿发病和死亡的一个风险因素。本研究聚焦于与对照组相比，人类糖尿病胎盘和胎儿胰腺中的自噬过程。对自噬标志物微管相关蛋白1轻链3（LC3）、贝林蛋白1（Beclin-1）和p62的分析表明，糖尿病胎盘的自噬过程受损。结果表明妊娠期糖尿病与自噬之间存在关联，强调了阐明调节这种关系的机制的重要性。
