Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF, Mexico.
Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF, Mexico.
Ageing Res Rev. 2017 Aug;37:135-145. doi: 10.1016/j.arr.2017.06.001. Epub 2017 Jun 15.
Wnt signaling is a highly conserved pathway that participates in multiple aspects of cellular function during development and in adults. In particular, this pathway has been implicated in cell fate determination, proliferation and cell polarity establishment. In the brain, it contributes to synapse formation, axonal remodeling, dendrite outgrowth, synaptic activity, neurogenesis and behavioral plasticity. The expression and distribution of Wnt components in different organs vary with age, which may have important implications for preserving tissue homeostasis. The dysregulation of Wnt signaling has been implicated in age-associated diseases, such as cancer and some neurodegenerative conditions. This is a relevant research topic, as an important research avenue for therapeutic targeting of the Wnt pathway in regenerative medicine has recently been opened. In this review, we discuss the recent findings on the regulation of Wnt components during aging, particularly in brain functioning, and the implications of Wnt signaling in age-related diseases.
Wnt 信号通路是一条高度保守的通路，参与了发育过程中和成人中细胞功能的多个方面。特别是，该通路参与了细胞命运决定、增殖和细胞极性建立。在大脑中，它有助于突触形成、轴突重塑、树突生长、突触活动、神经发生和行为可塑性。Wnt 成分在不同器官中的表达和分布随年龄而变化，这可能对维持组织内稳态具有重要意义。Wnt 信号通路的失调与年龄相关的疾病有关，如癌症和一些神经退行性疾病。这是一个相关的研究课题，因为最近开辟了一个重要的研究途径，即通过再生医学靶向 Wnt 通路进行治疗。在这篇综述中，我们讨论了最近关于 Wnt 成分在衰老过程中的调控的发现，特别是在大脑功能方面，以及 Wnt 信号通路在年龄相关疾病中的意义。
