Zang Minghui, He Wanting, Du Fanshu, Wu Gongjian, Wu Bohao, Zhou Zhenlei
College of Veterinary Medicine, Nanjing Agricultural University, No.1 Wei-Gang, Xuanwu District, Nanjing 210095, China.
College of Veterinary Medicine, Nanjing Agricultural University, No.1 Wei-Gang, Xuanwu District, Nanjing 210095, China.
Infect Genet Evol. 2017 Oct;54:54-59. doi: 10.1016/j.meegid.2017.06.013. Epub 2017 Jun 16.
Feline calicivirus (FCV) is a highly prevalent pathogen of the domestic cat that causes acute infections of the oral and upper respiratory tract. The E region of the ORF2 protein is responsible for the induction of virus-neutralizing antibodies, thus it is important to understand the codon usage of this gene. Here, analysed 90 coding sequences of ORF2 and show that it undergoes a low codon usage bias. In addition, although mutational bias is one of the factors shaping the codon usage bias of this gene, natural selection plays a more significant role. Our results reveal part of the mechanisms driving FCV evolution, which will lay foundation for the further research of FCV.
猫杯状病毒（FCV）是家猫中一种高度流行的病原体，可引起口腔和上呼吸道的急性感染。ORF2蛋白的E区域负责诱导病毒中和抗体，因此了解该基因的密码子使用情况很重要。在此，分析了90个ORF2的编码序列，结果表明它的密码子使用偏好较低。此外，虽然突变偏好是影响该基因密码子使用偏好的因素之一，但自然选择起更重要的作用。我们的结果揭示了驱动FCV进化的部分机制，这将为FCV的进一步研究奠定基础。
