Immunoreactive somatostatin-28(1-12) is increased in Huntington's disease.
作者信息
Beal M F, Benoit R, Bird E D, Martin J B
出版信息
Neurosci Lett. 1985 May 23;56(3):377-80. doi: 10.1016/0304-3940(85)90272-1.
PMID:2862613
Abstract
Somatostatin-28(1-12) concentrations were measured in Huntington's disease (HD) postmortem tissue using a specific radioimmunoassay. Concentrations of immunoreactive somatostatin-28(1-12) were significantly increased in the caudate and putamen but were unchanged in cortical areas A9 and A17. Since somatostatin-28(1-12) terminates with the amino acids Arg-Glu-OH, we examined whether this dodecapeptide compound might exert a neurotoxic effect. Injections of somatostatin-28(1-12) into rat striatum showed no evidence of histologic damage.
摘要
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