Kot Barbara, Wierzchowska Kamila, Grużewska Agata, Lohinau Dzmitry
a Department of Microbiology , Institute of Biology, Siedlce University of Natural Sciences and Humanities , Siedlce , Poland.
b Department of Agricultural Experimentation , Siedlce University of Natural Sciences and Humanities , Siedlce , Poland.
Nat Prod Res. 2018 Jun;32(11):1299-1302. doi: 10.1080/14786419.2017.1340282. Epub 2017 Jun 18.
The aim of this study was to evaluate the ability of 0.1% thyme oil (TO), trans-cinnamaldehyde (TC), ferulic acid (FA), p-coumaric acid (p-CA), caffeic acid (CA), lavender essential oil (LO), geranium essential oil (GO) and tee tree oil (TTO) to control biofilms formed by methicillin-resistant Staphylococcus aureus (MRSA) strains. Depending on the strains, TO reduced 59.7-85% of biofilm mass, while TC 52.9-82.4% after 48 h of treatment. Reduction of metabolic activity of biofilms in ranges 79.3-86% and 85.9-88.7% was observed after 48 h of TC and TO of treatment, respectively. In the case of some strains, reduction of biofilm mass in the presence of FA, CA, GO, LO and TTO was not observed. This study showed that TO and TC might have therapeutic potential as an inhibitory agents for use in MRSA biofilm-related infections.
本研究的目的是评估0.1%百里香油（TO）、反式肉桂醛（TC）、阿魏酸（FA）、对香豆酸（p-CA）、咖啡酸（CA）、薰衣草精油（LO）、天竺葵精油（GO）和茶树油（TTO）控制耐甲氧西林金黄色葡萄球菌（MRSA）菌株形成生物膜的能力。根据菌株不同，处理48小时后，TO使生物膜量减少59.7%-85%，而TC使生物膜量减少52.9%-82.4%。分别用TC和TO处理48小时后，观察到生物膜的代谢活性降低幅度分别为79.3%-86%和85.9%-88.7%。在某些菌株中，未观察到FA、CA、GO、LO和TTO存在时生物膜量的减少。本研究表明，TO和TC作为用于MRSA生物膜相关感染的抑制剂可能具有治疗潜力。
