B 细胞亲和力成熟的主要限制是什么，我们可以通过接种疫苗驱动多少亲和力成熟？抗体反馈的作用。
What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? A Role for Antibody Feedback.
机构信息
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, United Kingdom.
School of Health and Biomedical Sciences, RMIT University, Bundoora 3083, Australia.
出版信息
Cold Spring Harb Perspect Biol. 2018 May 1;10(5):a028795. doi: 10.1101/cshperspect.a028795.
Abstract
We discuss the impact of antibody feedback on affinity maturation of B cells. Competition from epitope-specific antibodies produced earlier during the immune response leads to immune complex formation, which is essential for transport and deposition of antigen onto follicular dendritic cells (FDCs). It also reduces the concentration of free epitopes into the μm to nm range, which is essential for B-cell receptors (BCRs) to sense affinity-dependent changes in binding capacity. Antibody feedback may also induce epitope spreading, leading to a broader selection of epitopes recognized by newly emerging B-cell clones. This may be exploitable, providing ways to manipulate epitope usage induced by vaccination.
摘要
我们讨论了抗体反馈对 B 细胞亲和力成熟的影响。在免疫反应早期产生的针对表位的抗体的竞争导致免疫复合物的形成，这对于抗原运输和递呈到滤泡树突状细胞（FDCs）至关重要。它还将游离表位的浓度降低到μm 到 nm 范围，这对于 B 细胞受体（BCRs）感知结合能力的亲和力依赖性变化至关重要。抗体反馈也可能诱导表位扩展，导致新出现的 B 细胞克隆识别的表位范围更广。这可能是可利用的，提供了操纵疫苗诱导的表位使用的方法。
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