Mergeche Joanna L, Verghese Joe, Allali Gilles, Wang Cuiling, Beauchet Olivier, Kumar V G Pradeep, Mathuranath P S, Yuan Jennifer, Blumen Helena M
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
J Neuroimaging Psychiatry Neurol. 2016;1(2):73-78. doi: 10.17756/jnpn.2016-009. Epub 2016 Nov 3.
Motoric cognitive risk (MCR) syndrome is a recently described pre-dementia syndrome characterized by slow gait and cognitive complaints that has been implicated as a predictor of cognitive decline and dementia in older adults. Previous work suggests that cerebrovascular disease is associated with MCR. White matter hyperintensities (WMH) are postulated to be a product of cerebrovascular disease, and have been associated with impaired mobility and impaired cognition. This study aimed to determine if MCR is associated with regional WMH.
Two cross-cultural cohorts of non-demented older adults were examined: 174 from a French memory clinic (62.1% male, mean age 70.7 ± 4.3 years) and 184 from an Indian community-dwelling cohort (55.4% male, mean age 66.2 ± 5.2 years). Participants were evaluated for slow gait, cognitive complaints, and regional WMH via MRI (fluid attenuated inversion recovery) FLAIR sequence.
Overall, 20.7% of participants met criteria for MCR, and 72.9% of participants had WMH on FLAIR. WMH in the frontal, parieto-occipital, temporal, basal ganglia, cerebellum, or brainstem were not associated with MCR in either of the two cohorts.
WMH was not significantly associated with MCR in this studied sample of participants, suggesting that other cerebrovascular pathophysiological mechanisms, or combination of mechanisms, might underlie MCR.
运动认知风险（MCR）综合征是一种最近被描述的痴呆前综合征，其特征为步态缓慢和认知主诉，被认为是老年人认知衰退和痴呆的预测指标。先前的研究表明，脑血管疾病与MCR有关。白质高信号（WMH）被假定为脑血管疾病的产物，并且与行动能力受损和认知障碍有关。本研究旨在确定MCR是否与局部WMH有关。
对两个非痴呆老年人的跨文化队列进行了检查：一个来自法国记忆诊所的174名参与者（男性占62.1%，平均年龄70.7±4.3岁）和一个来自印度社区居住队列的184名参与者（男性占55.4%，平均年龄66.2±5.2岁）。通过MRI（液体衰减反转恢复）FLAIR序列对参与者的步态缓慢、认知主诉和局部WMH进行评估。
总体而言，20.7%的参与者符合MCR标准，72.9%的参与者在FLAIR上有WMH。额叶、顶枕叶、颞叶、基底神经节、小脑或脑干的WMH在两个队列中均与MCR无关。
在本研究的参与者样本中，WMH与MCR无显著关联，这表明其他脑血管病理生理机制或机制组合可能是MCR的基础。
