Mikhael Nancy W, Mansour Amira I, Salah El Din Esraa M, El Azab Mohammed Hammad, Salem Rehab M
Dr. Mikhael is a Professor of Dermatology and Andrology and Dr. Salem is an Assistant Professor of Dermatology and Andrology, Dermatology Department, Faculty of Medicine, at Benha University in Benha, Egypt.
Dr. Mansour is an Assistant Professor of Clinical and Chemical Pathology, Clinical and Chemical Pathology Department, Faculty of Medicine, at Benha University in Benha, Egypt.
J Clin Aesthet Dermatol. 2021 Dec;14(12):E69-E73.
Acne is a multifactorial disorder, and stress potentially plays a role in its pathogenesis.
We aimed to assess the serum levels of neurotensin in patients with acne vulgaris (AV) and investigate the relationship of these levels to quality of life (QoL), depression, anxiety, and stress.
The study included 60 patients with AV classified into mild (n=20), moderate (n=20), and severe (n=20) groups and 20 healthy, age-matched, sex-matched, and body mass index (BMI)-matched individuals in a control group. Patient QoL was assessed using the Dermatology Life Quality Index (DLQI). Each participant completed the Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS-10). Serum levels of neurotensin were measured with enzyme-linked immunosorbent assay (ELISA).
Neurotensin levels and scores from the three questionnaires were significantly higher among the patients with AV than the control subjects. They were also significantly elevated in patients with post-acne scars and hyperpigmentation and in those with severe acne.
It is well known that acne greatly impacts QoL and might be associated with depression, anxiety, and stress. Further, serum neurotensin could be a promising marker to objectively evaluate the psychosocial impact of AV.
痤疮是一种多因素疾病，压力可能在其发病机制中起作用。
我们旨在评估寻常痤疮（AV）患者的血清神经降压素水平，并研究这些水平与生活质量（QoL）、抑郁、焦虑和压力之间的关系。
该研究纳入了60例AV患者，分为轻度（n = 20）、中度（n = 20）和重度（n = 20）组，以及20名年龄、性别和体重指数（BMI）匹配的健康个体作为对照组。使用皮肤病生活质量指数（DLQI）评估患者的生活质量。每位参与者完成医院焦虑抑郁量表（HADS）和感知压力量表（PSS - 10）。采用酶联免疫吸附测定（ELISA）法测量血清神经降压素水平。
AV患者的神经降压素水平和来自三个问卷的得分显著高于对照组。痤疮后瘢痕和色素沉着患者以及重度痤疮患者的神经降压素水平也显著升高。
众所周知，痤疮对生活质量有很大影响，可能与抑郁、焦虑和压力有关。此外，血清神经降压素可能是客观评估AV心理社会影响的一个有前景的标志物。
