依赖钙离子进入的软体动物神经元中钙电导的失活。
Inactivation of Ca conductance dependent on entry of Ca ions in molluscan neurons.
作者信息
Tillotson D
出版信息
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1497-500. doi: 10.1073/pnas.76.3.1497.
Abstract
Inactivation of the Ca channel of Aplysia neurons was studied in the absence of potassium current in cells that were cesium-loaded with the aid of the ionophore nystatin. Inactivation was substantially decreased by methods that limited Ca entry. Depolarizations commensurate with the equilibrium potential of Ca resulted in minimal inactivation. Replacement of extracellular Ca by Ba also decreased inactivation. It is concluded that inactivation of the Ca channel is a function of the extent of Ca entry rather than membrane potential, thus differing fundamentally from the purely voltage-dependent mechanism for sodium inactivation.
摘要
在借助离子载体制霉菌素用铯加载的细胞中，在无钾电流的情况下研究了海兔神经元钙通道的失活。通过限制钙内流的方法，失活显著降低。与钙平衡电位相当的去极化导致最小程度的失活。用钡替代细胞外钙也降低了失活。得出的结论是，钙通道的失活是钙内流程度的函数，而非膜电位的函数，因此与钠失活的纯电压依赖性机制有根本区别。
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