肝脏疾病中的细胞外囊泡。
Extracellular vesicles in liver diseases.
作者信息
Maji Sayantan, Matsuda Akiko, Yan Irene K, Parasramka Mansi, Patel Tushar
机构信息
Department of Transplantation and Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida.
Department of Transplantation and Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida
出版信息
Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G194-G200. doi: 10.1152/ajpgi.00216.2016. Epub 2016 Dec 30.
Abstract
Extracellular vesicles (EVs) are membrane-bound vesicles that are released by cells into their extracellular environment, have selective enrichment of specific proteins and RNA, and can mediate intercellular communication. In this review we highlight recent observations of the role of EVs in liver injury, viral hepatitis, alcoholic or nonalcoholic liver disease, biliary tract disease, and liver cancers. Potential applications as markers of diseases or for therapeutic applications are outlined to emphasize the new opportunities that are arising from the study of EVs.
摘要
细胞外囊泡（EVs）是由细胞释放到细胞外环境中的膜结合囊泡，具有特定蛋白质和RNA的选择性富集，并且能够介导细胞间通讯。在本综述中，我们重点介绍了关于细胞外囊泡在肝损伤、病毒性肝炎、酒精性或非酒精性肝病、胆道疾病以及肝癌中作用的最新观察结果。概述了其作为疾病标志物或治疗应用的潜在用途，以强调细胞外囊泡研究带来的新机遇。
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