Institute for Complex Molecular Systems, Eindhoven University of Technology, De Zaale, 5612 AJ Eindhoven, The Netherlands.
SyMO-Chem BV, Eindhoven University of Technology, De Zaale, 5612 AZ Eindhoven, The Netherlands.
Biomater Sci. 2017 Jul 25;5(8):1541-1548. doi: 10.1039/c7bm00407a.
Optimization of cell-material interactions is crucial for the success of synthetic biomaterials in guiding tissue regeneration. To do so, catechol chemistry is often used to introduce adhesiveness into biomaterials. Here, a supramolecular approach based on ureido-pyrimidinone (UPy) modified polymers is combined with catechol chemistry in order to achieve improved cellular adhesion onto supramolecular biomaterials. UPy-modified hydrophobic polymers with non-cell adhesive properties are developed that can be bioactivated via a modular approach using UPy-modified catechols. It is shown that successful formulation of the UPy-catechol additive with the UPy-polymer results in surfaces that induce cardiomyocyte progenitor cell adhesion, cell spreading, and preservation of cardiac specific extracellular matrix production. Hence, by functionalizing supramolecular surfaces with catechol functionalities, an adhesive supramolecular biomaterial is developed that allows for the possibility to contribute to biomaterial-based regeneration.
优化细胞-材料相互作用对于合成生物材料在引导组织再生中的成功至关重要。为此，儿茶酚化学通常用于向生物材料中引入粘附性。在这里，基于脲嘧啶嘧啶酮（UPy）修饰聚合物的超分子方法与儿茶酚化学结合，以实现对超分子生物材料上细胞粘附的改善。开发了具有非细胞粘附特性的 UPy 修饰疏水性聚合物，可通过使用 UPy 修饰儿茶酚的模块化方法进行生物激活。结果表明，成功地将 UPy-儿茶酚添加剂与 UPy-聚合物进行配方处理后，得到的表面能够诱导心肌细胞前体细胞的粘附、细胞铺展以及保留心脏特异性细胞外基质的产生。因此，通过用儿茶酚官能团功能化超分子表面，开发了一种具有粘附性的超分子生物材料，为基于生物材料的再生提供了可能性。
