Ippel Bastiaan D, Komil Muhabbat I, Bartels Paul A A, Söntjens Serge H M, Boonen Roy J E A, Smulders Maarten M J, Dankers Patricia Y W
Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Laboratory for Cell and Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Macromolecules. 2020 Jun 9;53(11):4454-4464. doi: 10.1021/acs.macromol.0c00160. Epub 2020 May 26.
Surface-initiated controlled radical polymerization is a popular technique for the modification of biomaterials with, for example, antifouling polymers. Here, we report on the functionalization of a supramolecular biomaterial with zwitterionic poly(sulfobetaine methacrylate) via atom transfer radical polymerization from a macroinitiator additive, which is embedded in the hard phase of the ureido-pyrimidinone-based material. Poly(sulfobetaine methacrylate) was successfully polymerized from these surfaces, and the polymerized sulfobetaine content, with corresponding antifouling properties, depended on both the macroinitiator additive concentration and polymerization time. Furthermore, the polymerization from the macroinitiator additive was successfully translated to functional electrospun scaffolds, showing the potential for this functionalization strategy in supramolecular material systems.
表面引发的可控自由基聚合是一种用于用例如抗污聚合物修饰生物材料的常用技术。在此，我们报道了通过原子转移自由基聚合，从嵌入基于脲嘧啶酮材料硬相中的大分子引发剂添加剂出发，用两性离子聚（甲基丙烯酸磺酸甜菜碱）对超分子生物材料进行功能化。聚（甲基丙烯酸磺酸甜菜碱）成功地从这些表面聚合，并且具有相应抗污性能的聚合磺酸甜菜碱含量取决于大分子引发剂添加剂浓度和聚合时间。此外，从大分子引发剂添加剂出发的聚合成功地转化到了功能化的电纺支架上，显示了这种功能化策略在超分子材料体系中的潜力。
