AKT modulates the autophagy-lysosome pathway via TFEB.
作者信息
Palmieri Michela, Pal Rituraj, Sardiello Marco
机构信息
a Department of Molecular and Human Genetics, Baylor College of Medicine , Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital , Houston , Texas , USA.
b Department of Molecular Physiology and Biophysics , Baylor College of Medicine , Houston , Texas , USA.
出版信息
Cell Cycle. 2017 Jul 3;16(13):1237-1238. doi: 10.1080/15384101.2017.1337968. Epub 2017 Jun 21.
Abstract
摘要
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本文引用的文献
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AKT/PKB Signaling: Navigating the Network.AKT/蛋白激酶B信号传导：探索该网络
Cell. 2017 Apr 20;169(3):381-405. doi: 10.1016/j.cell.2017.04.001.
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mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.通过抑制 Akt 实现 mTORC1 独立的 TFEB 激活促进神经退行性贮积病中的细胞清除。
Nat Commun. 2017 Feb 6;8:14338. doi: 10.1038/ncomms14338.
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Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases.转录因子EB：从溶酶体途径的主要协调者到退行性贮积病的候选治疗靶点
Ann N Y Acad Sci. 2016 May;1371(1):3-14. doi: 10.1111/nyas.13131.
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Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults.口服海藻糖补充剂可改善健康中老年人的阻力动脉内皮功能。
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Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis.海藻糖抑制溶质载体2A（SLC2A）蛋白以诱导自噬并预防肝脂肪变性。
Sci Signal. 2016 Feb 23;9(416):ra21. doi: 10.1126/scisignal.aac5472.
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The role of autophagy in neurodegenerative disease.自噬在神经退行性疾病中的作用。
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A gene network regulating lysosomal biogenesis and function.一个调节溶酶体生物发生和功能的基因网络。
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