Alberts Melissa, Groom Robert C, Walczak Richard, Kramer Robert, Karpiel Adrienne, Dieter Jeanette, Sheth Lisa, Greene Nathaniel H, Jooste Edmund H
Division of Cardiovascular and Thoracic Surgery, Department of Perfusion Services, Duke University Hospital, Durham, North Carolina.
Maine Cardiovascular Institute, Maine Medical Center, Portland, Maine.
J Extra Corpor Technol. 2017 Jun;49(2):107-111.
Use of autotransfusion systems to collect, wash, and concentrate shed blood during surgical procedures is a widely used method for reducing postoperative anemia and the need for blood transfusions. The aim of this study was to evaluate the CATSmart Continuous Autotransfusion System wash program performance with small (200 or 700 mL) and large volumes (1,000 mL) of shed blood and to determine non-inferiority of the CATSmart to the C.A.T.S system. Human whole blood was collected in citrate phosphate dextrose, diluted, and divided into two aliquots to be processed as a pair using the C.A.T.S and CATSmart systems with their corresponding wash programs: low-volume, high quality/smart, or emergency wash. Final packed red cell product was analyzed for red blood cell (RBC), white blood cell, and platelet counts; hemoglobin; hemolysis; RBC recovery rates; and elimination of albumin, total protein, and potassium. The mean hematocrit (HCT) after processing with CATSmart and C.A.T.S systems were 59.63% and 57.71%, respectively. The calculated overall RBC recovery rates on the CATSmart and C.A.T.S systems were 85.41% and 84.99%, respectively. Elimination of albumin (97.5%, 98.0%), total proteins (97.1%, 97.5%), and potassium (92.1%, 91.9%) were also calculated for the CATSmart and C.A.T.S systems. The CATSmart and C.A.T.S systems both provided a high-quality product in terms of HCT, protein elimination, and hemolysis rates across the range of tested shed blood volumes and all wash programs. The study was able to confirm the CATSmart is non-inferior to the C.A.T.S system.
在外科手术过程中使用自体输血系统来收集、清洗和浓缩失血是一种广泛应用的减少术后贫血和输血需求的方法。本研究的目的是评估CATSmart连续自体输血系统在处理少量（200或700毫升）和大量（1000毫升）失血时的清洗程序性能，并确定CATSmart相对于C.A.T.S系统的非劣效性。将人全血采集到枸橼酸盐磷酸盐葡萄糖溶液中，进行稀释，然后分成两份作为一组，分别使用C.A.T.S系统和CATSmart系统及其相应的清洗程序（低容量、高质量/智能或紧急清洗）进行处理。对最终的红细胞浓缩产品进行红细胞、白细胞和血小板计数、血红蛋白、溶血、红细胞回收率以及白蛋白、总蛋白和钾的清除率分析。使用CATSmart系统和C.A.T.S系统处理后的平均血细胞比容（HCT）分别为59.63%和57.71%。计算得出，CATSmart系统和C.A.T.S系统的总体红细胞回收率分别为85.41%和84.99%。还计算了CATSmart系统和C.A.T.S系统白蛋白（97.5%，98.0%）、总蛋白（97.1%，97.5%）和钾（92.1%，91.9%）的清除率。在所有测试的失血量范围和所有清洗程序中，就HCT、蛋白质清除率和溶血率而言，CATSmart系统和C.A.T.S系统均提供了高质量的产品。该研究能够证实CATSmart系统不劣于C.A.T.S系统。
