Madikizela Lawrence Mzukisi, Chimuka Luke
Department of Chemistry, Durban University of Technology, PO Box 1334, Durban, 4000, South Africa.
Molecular Sciences Institute, University of Witwatersrand, Private Bag x3, Johannesburg, 2050, South Africa.
Environ Monit Assess. 2017 Jul;189(7):348. doi: 10.1007/s10661-017-6069-1. Epub 2017 Jun 21.
The present paper reports a detailed study that is based on the monitoring of naproxen, ibuprofen, and diclofenac in Mbokodweni River and wastewater treatment plants (WWTPs) located around the city of Durban in KwaZulu-Natal Province of South Africa. Target compounds were extracted from water samples using a multi-template molecularly imprinted solid-phase extraction prior to separation and quantification on a high-performance liquid chromatography equipped with photo diode array detector. The analytical method yielded the detection limits of 0.15, 1.00, and 0.63 μg/L for naproxen, ibuprofen, and diclofenac, respectively. Solid-phase extraction method was evaluated for its performance using deionized water samples that were spiked with 5 and 50 μg/L of target compounds. Recoveries were greater than 80% for all target compounds with RSD values in the range of 4.1 to 10%. Target compounds were detected in most wastewater and river water samples with ibuprofen being the most frequently detected pharmaceutical. Maximum concentrations detected in river water for naproxen, ibuprofen, and diclofenac were 6.84, 19.2, and 9.69 μg/L, respectively. The concentrations of target compounds found in effluent and river water samples compared well with some studies. The analytical method employed in this work is fast, selective, sensitive, and affordable; therefore, it can be used routinely to evaluate the occurrence of acidic pharmaceuticals in South African water resources.
本文报道了一项详细研究，该研究基于对南非夸祖鲁 - 纳塔尔省德班市周边姆博科德韦尼河及污水处理厂中萘普生、布洛芬和双氯芬酸的监测。在配备光电二极管阵列检测器的高效液相色谱仪上进行分离和定量之前，使用多模板分子印迹固相萃取法从水样中提取目标化合物。该分析方法对萘普生、布洛芬和双氯芬酸的检测限分别为0.15、1.00和0.63μg/L。使用添加了5和50μg/L目标化合物的去离子水样品评估固相萃取方法的性能。所有目标化合物的回收率均大于80%，相对标准偏差值在4.1%至10%之间。在大多数废水和河水样品中检测到目标化合物，其中布洛芬是最常检测到的药物。河水中萘普生、布洛芬和双氯芬酸的最大检测浓度分别为6.84、19.2和9.69μg/L。废水和河水样品中发现的目标化合物浓度与一些研究结果相当。本研究采用的分析方法快速、选择性强、灵敏且经济实惠；因此，它可常规用于评估南非水资源中酸性药物的存在情况。
