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Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies.神经胶质瘤干细胞的不同干性状态维持神经胶质瘤亚型，提示新的临床生物标志物和高疗效的定制化治疗方法。
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本文引用的文献

1
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.通过单细胞RNA测序解析IDH突变型胶质瘤中的遗传学、谱系和微环境
Science. 2017 Mar 31;355(6332). doi: 10.1126/science.aai8478.
2
Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression.胶质母细胞瘤癌症干细胞通过降低Toll样受体4（TLR4）的表达逃避先天免疫对自我更新的抑制。
Cell Stem Cell. 2017 Apr 6;20(4):450-461.e4. doi: 10.1016/j.stem.2016.12.001. Epub 2017 Jan 12.
3
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.适应性染色质重塑驱动胶质母细胞瘤干细胞可塑性和耐药性。
Cell Stem Cell. 2017 Feb 2;20(2):233-246.e7. doi: 10.1016/j.stem.2016.11.003. Epub 2016 Dec 15.
4
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma.单细胞RNA测序支持人类少突胶质细胞瘤的发育层次结构。
Nature. 2016 Nov 10;539(7628):309-313. doi: 10.1038/nature20123. Epub 2016 Nov 2.
5
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance.阻断前列腺素E2诱导的肿瘤再增殖可消除膀胱癌的化疗耐药性。
Nature. 2015 Jan 8;517(7533):209-13. doi: 10.1038/nature14034. Epub 2014 Dec 3.
6
Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma.大多数人类非 GCIMP 胶质母细胞瘤亚型起源于常见的神经前体细胞样前胶质瘤。
Cancer Cell. 2014 Aug 11;26(2):288-300. doi: 10.1016/j.ccr.2014.06.005.
7
Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.静止 Sox2(+) 细胞驱动 Sonic Hedgehog 亚组髓母细胞瘤的层级生长和复发。
Cancer Cell. 2014 Jul 14;26(1):33-47. doi: 10.1016/j.ccr.2014.05.005. Epub 2014 Jun 19.
8
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.突变分析揭示了复发性神经胶质瘤的起源和治疗驱动的进化。
Science. 2014 Jan 10;343(6167):189-193. doi: 10.1126/science.1239947. Epub 2013 Dec 12.
9
Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype.原发性脑胶质瘤细胞对治疗的反应具有个体差异性，且与肿瘤干细胞表型无关。
Neuro Oncol. 2014 Mar;16(3):361-71. doi: 10.1093/neuonc/not223. Epub 2013 Dec 4.
10
A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity.小脑内表达巢蛋白的祖细胞群体具有更高的致瘤性。
Nat Neurosci. 2013 Dec;16(12):1737-44. doi: 10.1038/nn.3553. Epub 2013 Oct 20.

Brain Tumor Stem Cells Remain in Play.

作者信息

Parada Luis F, Dirks Peter B, Wechsler-Reya Robert J

机构信息

Luis F. Parada, Memorial Sloan Kettering Cancer Center, New York, NY; Peter B. Dirks, University of Toronto, Toronto, Ontario, Canada; and Robert J. Wechsler-Reya, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.

出版信息

J Clin Oncol. 2017 Jul 20;35(21):2428-2431. doi: 10.1200/JCO.2017.73.9540. Epub 2017 Jun 22.

DOI:10.1200/JCO.2017.73.9540
PMID:28640710
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5516484/
Abstract
摘要