School of Medicine, Queen's University, Kingston, ON, Canada.
Dermatology. 2017;233(2-3):120-125. doi: 10.1159/000477207. Epub 2017 Jun 23.
Hidradenitis suppurativa (HS) is a disease characterized by the development of painful, deep-seeded nodules and abscesses. Treatment guidelines include a combination of lifestyle, surgical, and medical interventions. Isotretinoin has not been included in the treatment guidelines due to the limited number of studies and conflicting reports of efficacy.
The purpose of this study is to evaluate the clinical response to isotretinoin in HS patients and to determine whether there is a particular patient population that may benefit more from this treatment.
A retrospective chart review was conducted on all HS patients treated with isotretinoin within the years of 2014-2016. Sex, age, weight, history of acne, Hurley stage, and treatment dose and duration were extracted from patient charts.
Of the 25 patients included in the study, 32% (8/25) had no response, 32% (8/26) showed partial response, and 36% (9/25) demonstrated complete response to isotretinoin treatment. Complete response was seen only in Hurley stage I and II patients. Hurley III patients made up 50% of the non-responders. Those with any sort of treatment response were more likely to be female, younger, weigh less, and have a higher prevalence of acne compared to non-responders.
This is a retrospective chart review with a small sample size of 25 patients.
Physicians should consider isotretinoin as a potential treatment for HS, as it may be beneficial in patients with mild and moderate disease and patients who are female, younger, weigh less, and have a personal history of acne.
化脓性汗腺炎（HS）是一种以疼痛、深在性结节和脓肿为特征的疾病。治疗指南包括生活方式、手术和医疗干预的综合措施。异维 A 酸由于研究数量有限且疗效报告存在矛盾，因此未被纳入治疗指南。
本研究旨在评估异维 A 酸治疗 HS 患者的临床疗效，并确定是否存在某种特定的患者群体可能从这种治疗中获益更多。
对 2014 年至 2016 年间接受异维 A 酸治疗的所有 HS 患者进行回顾性图表审查。从患者图表中提取性别、年龄、体重、痤疮病史、Hurley 分期以及治疗剂量和持续时间。
在 25 名纳入研究的患者中，32%（8/25）无反应，32%（8/26）部分反应，36%（9/25）完全反应。完全反应仅见于 Hurley 分期 I 和 II 患者。Hurley III 期患者中有 50%为无反应者。有任何治疗反应的患者与无反应者相比，更可能为女性、年龄更小、体重更轻、且痤疮患病率更高。
这是一项回顾性图表审查，样本量较小，仅有 25 名患者。
鉴于异维 A 酸对轻度和中度疾病患者以及女性、年轻、体重较轻且有痤疮病史的患者可能有益，医生应考虑将其作为 HS 的潜在治疗方法。
