Taibbi Giovanni, Cromwell Ronita L, Zanello Susana B, Yarbough Patrice O, Ploutz-Snyder Robert J, Godley Bernard F, Vizzeri Gianmarco
Aerosp Med Hum Perform. 2017 Jul 1;88(7):633-640. doi: 10.3357/AMHP.4768.2017.
We evaluated ophthalmic changes in healthy individuals who underwent integrated resistance and aerobic training (iRAT) during 70-d 6° head-down tilt (HDT) bed rest (BR).
Participants were selected using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects were randomly assigned to the iRAT protocol or no exercise during HDTBR. Weekly ophthalmic examinations were performed in the sitting (pre/post-BR only) and HDT (BR only) positions. Mixed-effects linear models compared pre- and post-HDTBR intraocular pressure (IOP), Spectralis OCT circumpapillary retinal nerve fiber layer (cpRNFL) thickness, and peripapillary retinal thickness observations between groups.
Six controls and nine exercisers completed the study. There was an overall effect of BR on our outcomes. Except Goldmann IOP (mean pre/post difference in controls and exercisers: -0.47 mmHg vs. +1.14 mmHg), the magnitude of changes from baseline was not significantly different between groups. There was a +1.38 mmHg and a +1.63 mmHg iCare IOP increase during BR in controls and exercisers, respectively. Spectralis OCT detected a +1.33 μm average cpRNFL thickness increase in both groups, and a +9.77 μm and a +6.65 μm peripapillary retinal thickening post-BR in controls and exercisers, respectively. Modified Amsler grid, red dot test, confrontational visual field, color vision, and stereoscopic fundus photography were unremarkable.
HDTBR for 70 d induced peripapillary retinal thickening and cpRNFL thickening without visible signs of optic disc edema. The magnitude of such changes was not different between controls and exercisers. A slight IOP increase during BR subsided post-BR. Further study should evaluate whether different physical exercise paradigms may prevent/mitigate the risk of space-related visual impairment.Taibbi G, Cromwell RL, Zanello SB, Yarbough PO, Ploutz-Snyder RJ, Godley BF, Vizzeri G. Ophthalmological evaluation of integrated resistance and aerobic training during 70-day bed rest. Aerosp Med Hum Perform. 2017; 88(7):633-640.
我们评估了健康个体在70天6°头低位倾斜（HDT）卧床休息（BR）期间进行综合抗阻和有氧训练（iRAT）时的眼部变化。
采用美国国家航空航天局（NASA）标准筛选程序选取参与者。实施标准化的NASA BR条件。受试者在HDTBR期间被随机分配到iRAT方案组或不进行运动组。在坐位（仅BR前/后）和HDT位（仅BR期间）每周进行眼科检查。混合效应线性模型比较了HDTBR前后两组间的眼压（IOP）、Spectralis OCT视乳头周围视网膜神经纤维层（cpRNFL）厚度和视乳头周围视网膜厚度观察结果。
6名对照组和9名运动组完成了研究。BR对我们的研究结果有总体影响。除了Goldmann眼压（对照组和运动组的平均前后差异：-0.47 mmHg对+1.14 mmHg）外，两组间与基线相比的变化幅度无显著差异。对照组和运动组在BR期间iCare眼压分别升高了1.38 mmHg和1.63 mmHg。Spectralis OCT检测到两组视乳头周围视网膜神经纤维层平均厚度均增加了1.33 μm，对照组和运动组在BR后视乳头周围视网膜分别增厚了9.77 μm和6.65 μm。改良Amsler方格表、红点试验、对 confrontation 视野、色觉和立体眼底摄影均无异常。
70天的HDTBR导致视乳头周围视网膜增厚和cpRNFL增厚，且无视盘水肿的明显迹象。对照组和运动组之间这种变化的幅度没有差异。BR期间眼压略有升高，BR后消退。进一步的研究应评估不同的体育锻炼模式是否可预防/减轻与太空相关的视力损害风险。Taibbi G、Cromwell RL、Zanello SB、Yarbough PO、Ploutz-Snyder RJ、Godley BF、Vizzeri G。70天卧床休息期间综合抗阻和有氧训练的眼科评估。航空航天医学与人类表现。2017；88（7）：633 - 640。
