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小儿冲击波碎石术的程序性镇静和镇痛:单机构 10 年经验。

Procedural sedation and analgesia for pediatric shock wave lithotripsy: a 10 year experience of single institution.

机构信息

Dr. Lütfi Kirdar Training and Research Hospital, Anesthesiology and Reanimation Clinic, Şemsi Denizer caddesi, 34865, Cevizli-Kartal, Istanbul, Turkey.

Dr. Lütfi Kirdar Training and Research Hospital, Urology Clinic, Şemsi Denizer caddesi, 34865, Cevizli-Kartal, Istanbul, Turkey.

出版信息

Urolithiasis. 2018 Aug;46(4):363-367. doi: 10.1007/s00240-017-0992-z. Epub 2017 Jun 22.

DOI:10.1007/s00240-017-0992-z
PMID:28642966
Abstract

The aim of this study was to evaluate anesthesia practice for pediatric extracorporeal shock wave lithotripsy (ESWL) according to the age groups and discuss the anesthetic management of these patients. Pediatric patients treated with ESWL because of urolithiasis under anesthesia in our department between December 2007 and January 2017 were evaluated retrospectively. A total of 251 patients were divided into two groups as Group PS: preschool children (<6 years) and Group S: school children (≥6 years). Groups were compared according to ketamine and midazolam doses, extra anesthetic agent requirement, duration of procedure, procedural and postprocedural complications due to anesthesia, as well as mean number of sessions and calculus diameter. A total of 408 sessions of ESWL were applied to 251 children included in the study. Overall, mean age of the patients was 4.5 ± 3.2 years (7 months-14 years). In school children (Group S), mean ketamine and midazolam doses were significantly higher than the preschool group (p < 0.01 and p = 0.04, respectively). There was no statistically significant difference in additional anesthetic agent requirement (p = 0.35) as well as mean number of SWL sessions (p = 0.23), duration of anesthesia (p = 0.93), stone size (p = 0.20), and stone laterality (p = 0.71) in both preschool and school children. No severe complications were observed in both groups. In pediatric ESWL patients, ketamine-midazolam combination is an effective and safety choice for outpatient anesthesia. Appropriate dose adjustment in a monitorized and well-equipped setting is essential.

摘要

本研究旨在评估根据年龄组对小儿体外冲击波碎石术(ESWL)的麻醉实践,并讨论这些患者的麻醉管理。回顾性评估了 2007 年 12 月至 2017 年 1 月期间我科因尿路结石接受 ESWL 治疗的麻醉小儿患者。共有 251 例患者分为两组:PS 组:学龄前儿童(<6 岁)和 S 组:学龄儿童(≥6 岁)。比较了两组患儿的氯胺酮和咪达唑仑剂量、麻醉以外的药物需求、手术时间、麻醉相关的手术和术后并发症,以及平均治疗次数和结石直径。共对 251 例儿童的 408 次 ESWL 进行了治疗。总的来说,患者的平均年龄为 4.5±3.2 岁(7 个月-14 岁)。在学龄儿童(S 组)中,氯胺酮和咪达唑仑的平均剂量明显高于学龄前儿童(p<0.01 和 p=0.04)。麻醉以外的药物需求(p=0.35)、ESWL 治疗次数(p=0.23)、麻醉时间(p=0.93)、结石大小(p=0.20)和结石侧位(p=0.71)在两组患儿中均无统计学差异。两组均未观察到严重并发症。在小儿 ESWL 患者中,氯胺酮-咪达唑仑联合是一种有效且安全的门诊麻醉选择。在监测和设备齐全的环境中进行适当的剂量调整至关重要。

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Extracorporeal shock wave lithotripsy in infants less than 12-month old.12个月以下婴儿的体外冲击波碎石术
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Neonatal Anesthesia by Ketamine in Neonatal Rats Inhibits the Proliferation and Differentiation of Hippocampal Neural Stem Cells and Decreases Neurocognitive Function in Adulthood via Inhibition of the Notch1 Signaling Pathway.氯胺酮对新生大鼠的新生儿麻醉通过抑制Notch1信号通路抑制海马神经干细胞的增殖和分化,并降低成年后的神经认知功能。
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