Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA.
Department of Medicine, National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA, USA.
Curr Top Microbiol Immunol. 2017;411:171-193. doi: 10.1007/82_2017_20.
Ebola virus disease (EVD) in humans is associated with four ebolaviruses: Ebola virus (EBOV), Sudan virus (SUDV), Bundibugyo virus (BDBV), and Taï Forest virus. To date, no documented cases of human disease have been associated with Reston virus. Here, we describe the nonhuman primate (NHP) models that currently serve as gold standards for testing ebolavirus vaccines and therapeutic agents and elucidating underlying mechanisms of pathogenesis. Although multiple models have been explored over the past 50 years, the predominance of published work has been performed in macaque models. This chapter will focus on the most commonly used models.
人类埃博拉病毒病（EVD）与四种埃博拉病毒有关：埃博拉病毒（EBOV）、苏丹病毒（SUDV）、本迪布焦病毒（BDBV）和塔伊森林病毒。迄今为止，尚未有文献记载与雷斯顿病毒有关的人类疾病病例。在这里，我们描述了目前用于测试埃博拉病毒疫苗和治疗剂以及阐明发病机制的基础机制的非人类灵长类动物（NHP）模型。尽管在过去的 50 年中已经探索了多种模型，但发表的工作主要集中在猕猴模型上。本章将重点介绍最常用的模型。
