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撤回:微小 RNA-497 通过下调心肌缺血再灌注损伤小鼠模型中的 Mfn2 促进心肌细胞增殖和抑制凋亡。

RETRACTED: MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury.

机构信息

Department of Cardiovascular Internal Medicine, Kaifeng Central Hospital, Kaifeng, 475000, PR China.

Department of Cardiovascular Internal Medicine, Kaifeng Central Hospital, Kaifeng, 475000, PR China.

出版信息

Biomed Pharmacother. 2018 Sep;105:103-114. doi: 10.1016/j.biopha.2018.04.181. Epub 2018 May 28.

DOI:10.1016/j.biopha.2018.04.181
PMID:29852387
Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. An Expression of Concern for this article was previously published while an investigation was conducted (see related editorial: https://doi.org/10.1016/j.biopha.2022.113812). This retraction notice supersedes the Expression of Concern published earlier. Concern was raised about the reliability of the images shown in Figure 1, and the Western blots in Figures 6C and 8E, which appear to contain similar features to those found in other publications, as detailed here: https://pubpeer.com/publications/5E5DF69C11DAD50FBE63CD4F95990F; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. Additional concerns were raised over the provenance of the flow cytometry data in Figure 10C, that appear to contain repeating features. Furthermore, the myocardial infarct images in Figure 5A appear to actually show brain slices. Independent analysis also identified additional suspected image duplications within Figures 3A and 4. The journal requested the corresponding author comment on these concerns and provide the associated raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.

摘要

本文已被撤回

请参阅爱思唯尔关于文章撤回的政策(https://www.elsevier.com/about/policies/article-withdrawal)。应主编要求撤回本文。在进行调查时,曾发表过对此文的关注声明(参见相关社论:https://doi.org/10.1016/j.biopha.2022.113812)。本撤稿通知取代了之前发表的关注声明。有人对图 1 所示图像的可靠性以及图 6C 和 8E 中的 Western blot 提出了质疑,这些图像似乎与其他出版物中的图像存在相似特征,详情如下:https://pubpeer.com/publications/5E5DF69C11DAD50FBE63CD4F95990F;以及这里:https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249。此外,还对图 10C 中的流式细胞术数据的来源提出了更多质疑,这些数据似乎存在重复特征。此外,图 5A 中的心肌梗死图像实际上似乎显示的是脑切片。独立分析还在图 3A 和 4 中发现了其他疑似图像重复。期刊要求通讯作者对这些问题发表评论并提供相关原始数据。作者未对此请求作出回应,因此主编决定撤回该文章。

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