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撤回:苦参碱通过 JAK2/STAT3 信号通路抑制大鼠心肌微血管内皮细胞缺氧/复氧诱导的细胞凋亡。

RETRACTED: Matrine inhibits hypoxia/reoxygenation-induced apoptosis of cardiac microvascular endothelial cells in rats via the JAK2/STAT3 signaling pathway.

机构信息

Emergency Department, Jining NO.1 People's Hospital, Jining 272011, PR China.

Department of Cardiovascular, Rizhao Central Hospital, Rizhao 276800, PR China.

出版信息

Biomed Pharmacother. 2018 Oct;106:117-124. doi: 10.1016/j.biopha.2018.06.003. Epub 2018 Jun 26.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. An Expression of Concern for this article was previously published while an investigation was conducted (see related editorial: https://doi.org/10.1016/j.biopha.2022.113812). This retraction notice supersedes the Expression of Concern published earlier. Concerns were raised about the provenance of the flow cytometry data shown in Figure 5A, as detailed here: https://pubpeer.com/publications/46C8B5439C5C617A60494BA4C15479; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. Independent analysis also identified additional suspected image duplications between the Bax and Bcl-2 Western blots in Figure 6A. The journal requested the corresponding author comment on these concerns and provide the associated raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.

摘要

这篇文章已被撤回

请参阅 Elsevier 撤稿政策(http://www.elsevier.com/locate/withdrawalpolicy)。应主编要求撤回了这篇文章。在进行调查的同时,曾发表过一篇关注该文章的声明(见相关社论:https://doi.org/10.1016/j.biopha.2022.113812)。本撤稿通知取代了早先发表的关注声明。对图 5A 中显示的流式细胞术数据的来源提出了质疑,详见:https://pubpeer.com/publications/46C8B5439C5C617A60494BA4C15479;和这里:https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249。独立分析还发现图 6A 中 Bax 和 Bcl-2 Western blot 之间存在其他疑似图像重复。期刊要求通讯作者对这些关注进行评论并提供相关原始数据。作者未对此请求作出回应,因此主编决定撤回该文章。

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